A CLINICAL EVALUATION OF A PIPERIDINE COMPOUND ALONE, AND COMBINED WITH CALCIUM INTRAVENOUSLY IN ANTIHISTAMINE THERAPY

[摘要] Sandostene (1-methyl-4-amino-N:phenyl-N''(2''_thenyl)-piperidine_tartrate was given orally to 110 subjects with the following results: excellent 11; good 69; failure 26; doubtful 4. Sandostene plus Neocalglucon (calcium glucono-galactogluconate) was given intravenously to 25 subjects with the following results: excellent 5; good 16; failure 3; doubtful 1. Side actions consisted of 1 case of cramps and diarrhea 1/2 hour after ingestion of each tablet. Drowsiness followed more than 2 tablets by mouth and all instances of intravenous medication. No instance of toxicity was encountered. The incidence of side effects was lower than that reported with equivalent doses of other histamine antagonists at present in general use. The combination of Neocalglucon and Sandostene seems to be low in toxicity and highly suitable to supplement and widen the therapeutic range of Ca. The combination is well tolerated and possesses high antipermeability action resulting in manifold therapeutic effects which favor its use in treatment of the protean manifestations of allergic disease of the skin.