RADIOGRAPHIC MEASUREMENT OF TOPICAL CORTICOSTEROID-INDUCED ATROPHY

[摘要] Soft tissue X-ray techniques were used to measure skin thickness as influenced by the chronic usage of topical corticosteroids. In a double-blind study commercial preparations of 1% hydrocortisone (HC), 0.1% triamcinolone acetonide (TA), and a placebo cream were compared for their ability to produce atrophy in normal human forearm skin. After 8 wk of topical application of the creams, only TA produced clinically apparent atrophy. The average percent decreases in skin thickness measured after 8 wk of treatment with placebo, HC, or TA were 6.0%, 6.0% and 17.1%, respectively. During the 1st wk after cessation of treatment the clinical appearance of the skin began to improve and by 1 mo. all treated skin areas had essentially returned to pretreatment thickness.