SKIN SURFACE LIPID-COMPOSITION, ACNE, PUBERTAL DEVELOPMENT, AND URINARY-EXCRETION OF TESTOSTERONE AND 17-KETOSTEROIDS IN CHILDREN

[摘要] Fifty-two children, age 5-10, from acne-prone families, were studied for a period of 1 yr to examine the interrelationship between sebum, acne, pubertal development and urinary steroid excretion. In each of the subjects, 30 boys and 22 girls, the composition of forehead skin lipid was determined 4 times yearly by TLC, with measurement of triglycerides, diglycerides, free fatty acids, was esters, squalene, cholesterol and cholesterol esters. Twice yearly, examination was made of the presence or absence of acne, pubertal maturation and the 24 h urinary excretion of testosterone as determined by radioimmunoassay, and of total 17-ketosteroids, dehydroepiandrosterone, androsterone and etiocholanolone, as determined by paper chromatography. The relative amount of sebaceous lipids was positively correlated with age of the subjects (wax esters P < .001, squalene P < .05), as was the triglyceride-diglyceride component (P < .05). No significant correlation was seen with the fatty acids. Acne, primarily comedonal, occurred in 27/52 subjects (15 girls, 12 boys) and was associated with higher sebum values. One-half of the children with acne had no signs of pubertal development. A significantly positive correlation was observed between the relative amount of sebaceous lipid and the urinary excretion of 17-ketosteroids, androsterone and etiocholanolone in both sexes, and of testosterone and dehydroepiandrosterone in boys. The development of acne in children is an early pubertal event, often evident before other signs of pubertal maturation, and it is associated with an increase in sebum and inthe urinary excretion of androgenic steroids.