RESPONSE OF THE SKIN OF MICE TO METHYL ETHER OF VITAMIN-A AND VITAMIN-A PALMITATE

[摘要] When methyl ether of vitamin A and vitamin A palmitate were applied to 4 regions of skin in which the stages of growth of the hair follicles were controlled by timed plucking, the greatest amount of irritation occurred in the skin with resting hair follicles. Skin with growing follicles was relatively unaffected by these compounds. In the skin with resting follicles, which suffered a great deal of damage, after continued treatment the hair follicles became active. When this happened, the skin damage was repaired. These experiments show that the two compounds used do not inhibit - SH groups of keratinization in the mouse. The reaction of the skin with resting follicles to them is a generalized, non-specific stress response to an irritating agent.