STUDIES ON THE ECZEMATOUS SENSITIZATION .1. THE ROUTE BY WHICH THE SENSITIZATION GENERALIZES

[摘要] Guinea pigs were sensitized to 2,4-dihitrochlorbenzene and paranitrosodimethylaniline. At either 6, 12 or 24 hrs. the site of one of the eczematous applications was converted into an island by severing the epidermal and lymphatic pathways. This procedure did not seem to interfere with the generalization of the sensitization, except possibly that the islands became sensitized less often irrespective of whether the sensitizing application was to the island site or not. It is postulated that in an eczematous sensitization the simple allergen reacts at the site of application to form a conjugated or modified allergen. This new allergen is absorbed principally via lymphatics, but also by other routes.