Single-cell analysis of λ immunity regulation

[摘要] We have examined expression of the lambdacI operon in single cells via a rex:: gfp substitution. Although average fluorescence agreed with expectations for expression of X-repressor, fluorescence fluctuated greatly from cell-to-cell. Fluctuations in repressor concentration are not predicted by previous models and are tolerated in part by a regulatory response to DNA damage. (C) 2003 Elsevier Ltd. All rights reserved.

[发布日期] 2003-11-28

[关键词] bacteriophage lambda;repressor;GFP;single-cell analyses