General health and mortality in Tourette syndrome and chronic tic disorder: A mini-review

[摘要] Current knowledge on the general somatic health and causes of death in Tourette syndrome and chronic tic disorder is very limited. Here, we review the available literature on the topic, while highlighting strengths and weaknesses of the studies conducted to date. These previous works have suggested associations between Tourette syndrome and chronic tic disorder and a range of health conditions, including autoimmune disorders, common allergies and respiratory diseases, sleep difficulties, and metabolic and cardiovascular outcomes. Additionally, the risk of mortality in tic disorders might be higher than that of the general population, but specific causes of death have rarely been studied, except for substance use-related deaths and suicide, which are significantly higher in individuals with Tourette syndrome and chronic tic disorder. Many of these emerging findings require replication and extension but, taken together, they suggest that that it might be sensible to monitor the general health and suicide risk of individuals with Tourette syndrome or chronic tic disorder across the lifespan. We suggest further avenues for research on this topic.

[发布日期] 2020-12-01

[关键词] Tourette syndrome;Chronic tic disorder;Tic disorders;Somatic health;Autoimmune diseases;Allergies;Asthma;Sleep disorders;Metabolic syndrome;Cardiovascular diseases;Mortality;Premature death;Cause of death;Suicide