The cyclic AMP phenotype of fragile X and autism

[摘要] Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism. (c) 2008 Elsevier Ltd. All rights reserved

[发布日期] 2008-10-01

[关键词] Autism;Fragile X;Cyclic AMP;cAMP;Signal transduction;FMRP;FMR1