Functions of B56-containing PP2As in major developmental and cancer signaling pathways

[摘要] Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways. (C) 2010 Elsevier Inc. All rights reserved.

[发布日期] 2010-12-18

[关键词] PP2A;Regulatory subunit;B ';B56;PR61;Signaling pathways;Development;Tumorigenesis