Cardiovascular effects of the fungal extract of Basidiomycetes sp YL8006

[摘要] Many fungal products are known to possess biological activity towards the mammalian tissues. We studied vasodilating activity in the crude ethanol extract of the dried mycelia of Basidiomycetes sp. YL8006, cultured by submerged fermentation with a complex medium. The activity was assayed using the isolated perfused rat heart in the working mode. Immediately following injection of the extract into the perfusion system, a 20-25% increase in coronary flow was observed (p < 0.001 vs. solvent vehicle control). There was a concurrent decrease in diastolic pressure and coronary vascular resistance. Aortic flow, systolic pressure, and cardiac output declined slightly over time after treatment. No significant changes in heart rate, efficiency, and oxygen consumption were observed. Solvent vehicle did not cause any changes in hemodynamic performance.

[发布日期] 1997-04-25

[关键词] coronary vasodilator;hypotensive;vasorelaxation;isolated perfused rat heart;high performance liquid chromatography;natural product