Estrogen receptor-α mRNA variants in murine and human tissues

[摘要] A side-by-side comparison of several normal mouse and human tissues was undertaken in order to determine if exon-deleted variant ER-alpha mRNAs are expressed in the mouse. The data showed that the complex pattern of ER-alpha alternative splicing that is detected in multiple human tissues was not apparent in murine tissues. Only low levels of an exon-4 deleted ER-alpha transcript were detected in murine tissues, although multiple relatively abundant exon-deleted ER-alpha transcripts were detected in human tissues. The data support a species-specific difference in the expression of ER-alpha variant mRNAs between mouse and human. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

[发布日期] 1999-12-20

[关键词] alternative splicing;estrogen receptor-alpha;species differences;variant mRNAs