Pattern classification in DNA microarray data of multiple tumor types

[摘要] In this paper, we propose a genetic algorithm with silhouette statistics as discriminant function (GASS) for gene selection and pattern recognition. The proposed method evaluates gene expression patterns for discriminating heterogeneous cancers. Distance metrics and classification rules have also been analyzed to design a GASS with high classification accuracy. Moreover, the proposed method is compared to previously published methods. Various experimental results show that our method is effective for classifying the NCI60, the GCM and the SRBCTs datasets. Moreover, GASS outperforms other existing methods in both the leave-one-out cross validations and the independent test for novel data. (c) 2006 Pattern Recognition Society. Published by Elsevier Ltd. All rights reserved.

[发布日期] 2006-12-01

[关键词] gene expression profiling;cancer classification;genetic algorithm;silhouette statistics