DETERMINATION OF UVA PROTECTION FACTORS BY MEANS OF IMMEDIATE PIGMENT DARKENING IN NORMAL SKIN

[摘要] A method is described for screening potentially useful photoprotective agents against UVA radiation by the use of immediate pigment darkening as an end point. Threshold doses of immediate pigment darkening showed a log normal distribution and the response was found to obey dose-reciprocity at irradiance levels below 50 mW/cm2. With this procedure, several marketed sunscreens containing benzophenone-3 as the only UVA absorber were found to have poor UVA protection factors, whereas those containing combinations of benzophenone-3 and butyl methoxydibenzoyl methane or melanin were more effective. There was no correlation between the sun protection factor cited on the label and the calculated immediate pigment darkening-protection factor.

[发布日期] 1991-08-01