FIBRIN AND FIBRINOGEN-RELATED ANTIGENS IN SYSTEMIC-SCLEROSIS (SCLERODERMA)

[摘要] Abnormalities in fibrin deposition are implicated in the pathogenesis of vascular occlusion in systemic sclerosis. We have used a technique that involves electrophoresis and densitometric analysis of captured fibrin- and fibrinogen-related antigens to measure the concentration of the individual fibrin and fibrinogen degradation products in 13 patients with systemic sclerosis and in 15 healthy control subjects. As a group, patients with systemic sclerosis had markedly elevated levels of total fibrin-related antigen (p = 0.0007) and D-dimer (p = 0.0004), the terminal degradation product of cross-linked fibrin. The levels of fibrin monomer, an intermediate product in the conversion of fibrinogen to cross-linked fibrin, and Of D-monomer, a terminal breakdown fragment of fibrinogen and fibrin monomer, were also elevated (p < 0.005). We conclude that patients with systemic sclerosis have evidence of enhanced fibrin formation and degradation.

[发布日期] 1991-11-01