REGIONAL MYOCARDIAL BLOOD-FLOW IN EXPERIMENTAL MYOCARDIAL-INFARCTION AFTER PRETREATMENT WITH ASPIRIN

[摘要] The effects of aspirin on myocardial blood flow in an area of ischemia were studied in 12 baboons. In each, a diagonal branch of the left anterior descending coronary artery was ligated. Six of the the baboons received aspirin (2 .times. 600 mg orally, 12 hours and 1 hour before ligation); the other six did not receive aspirin and served as a control group. The extent of myocardial ischemia was delineated with an electrode wire grid on the surface of the anterior left ventricular wall. The maximal area circumscribed by electrodes with 2 mV or more ST segment elevation was compared with the area of reduced myocardial blood flow. Myocardial blood flow was measured with the radioactive microspheres method using strontium-85-labeled carbonized spheres. Two areas of reduced myocardial blood flow were noted, one with severely reduced flow in the center of the myocardial infarct (0 to 49% of noninfarcted myocardium) and another with mild to moderately reduced myocardial blood flow at the border of the myocardial infarct (5 to 90% of noninfarcted myocardium). Myocardial blood flow in the border area (margins of ST elevation area) for the total wall was 85 .+-. 8% of normal in the aspirin-treated animals and 40 .+-. 4% in the control group (p < 0.01); for the epicardium it was 67 .+-. 10% of normal in noninfarcted myocardium after aspirin and 37 .+-. 5% for the control group (p < 0.05); and for the endocardium it was 78 .+-. 8% of normal in noninfarcted myocardium after aspirin and 39 .+-. 6% in the control group (p < 0.01). The data demonstrate improved myocardial blood flow at the margins of an experimental infarct in primates pretreated with aspirin.

[发布日期] 1986-05-01