Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

[摘要] Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. Thisomic approach recently resulted in new targets for reducing CVD events. (C) 2014 by the American College of Cardiology Foundation.

[发布日期] 2014-12-16

[关键词] atherosclerosis;cardiovascular disease;genetics;triglyceride;triglyceride-rich lipoproteins