Clinician's Guide to Reducing Inflammation to Reduce Atherothrombotic Risk JACC Review Topic of the Week

[摘要] Life-threatening cardiovascular events occur despite control of conventional risk factors. Inflammation, as measured by high-sensitivity C-reactive protein (hsCRP) concentration, is associated with future vascular events in both primary and secondary prevention, independent of usual risk markers. Statins are powerful lipid-lowering agents with clinically relevant anti-inflammatory effects. Recent data support targeting the interleukin (IL)-1-to-IL-6-to-CRP signaling pathway as an adjunctive method for atheroprotection. The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcomes Study) trial showed that reducing inflammation through IL-1 beta inhibition significantly reduced vascular risk, beyond that achievable with lipid lowering. CANTOS further demonstrated a 31% reduction in cardiovascular mortality and all-cause mortality among patients treated with canakinumab who achieved the largest reductions in hsCRP, as well as efficacy in high-risk patients with chronic kidney disease and diabetes. This review outlines the clinical implications of CANTOS for patients withresidual inflammatory risk, the potential benefits and risks associated with anti-inflammatory therapy, and the importance of CANTOS for future drug development. (J Am Coll Cardiol 2018;72:3320-31) (c) 2018 by the American College of Cardiology Foundation.

[发布日期] 2018-12-25

[关键词] atherosclerosis;canakinumab;CANTOS;inflammation;interleukin-1