EFFECT OF METOPROLOL IN ACUTE COXSACKIEVIRUS-B3 MURINE MYOCARDITIS

[摘要] Recent studies suggest that beta-adrenergic blocking agents show promise in the management of cardiomyopathies; however, their role in acute myocarditis is unknown. One hundred 3 week old mice were infected with coxsackievirus B3 and were given either metoprolol (n = 50) or normal saline solution (n = 50) intraperitoneally for 10 days. Twenty mice from each group were observed for mortality for 30 days. Of the remaining 60 mice, 10 from each group were killed on day 3, 6 or 10 and examined for heart viral titers and pathologic changes. Mortality rate in the metoprolol group was 60% compared with 0% in the saline group (p < 0.005). Vital titers on day 10 of infection were 102.6 .+-. 0.2 median tissue culture infective dose for the metoprolol group versus 102.1 .+-. 0.1 for the saline group (p < 0.05). Whereas pathologic changes at days 3, 6 and 10 of infection were similar in both groups, on day 30 of infection, inflammation, necrosis and mineralization scores (mean .+-. SEM) were 1.1 .+-. 0.3, 2.1 .+-. 0.4, 2.2 .+-. 0.5 for the metoprolol group versus 0.3 .+-. 0.1, 0.4 .+-. 0.3, 0.4 .+-. 0.3 for the saline group, respectively (p < 0.01). Six noninfected mice received metoprolol intraperitoneally for 10 days; there was no mortality during 30 days of observation. In conclusion, metoprolol administration exerts deleterious effects in acute coxsackievirus B3 murine myocarditis.

[发布日期] 1988-08-01