Effect of response to a low-fat diet among adolescent males on their adult blood cholesterol levels

[摘要] Background. While primary prevention of adult cardiovascular diseases should bean early, there are problems in identifying children at increased risk of future disease. Methods. We did a follow-up study in 1991-1992 of 100 male former students at a boarding high school who had blood cholesterol measured in 1970-1971 both prior to and following a school-wide, reduced-fat dietary intervention, We compared adult cholesterol levels of the 50 subjects whose cholesterol decreased greater than or equal to 16.5% (the median decrease) following the 1970-1971 intervention (Diet-Sensitive) with the 50 whose response was <16.5% (Non-Diet-Sensitive). Results. Blood cholesterol of adults who were Diet-Sensitive in 1970-1971 was 4.2 mg/dl lower than their baseline values in adolescence, while adults classified as Non-Diet-Sensitive as adolescents showed a 15.9 mg/dl increase in cholesterol over 21 years. Adjusting for baseline adolescent values, Non-Diet-Sensitive subjects were 4.8 (95% CI 1.4, 15.9) times as likely as Diet-Sensitive subjects to have adult cholesterol greater than or equal to 200 mg/dl. Also, Diet-Sensitive adults on a low-fat diet had adult blood cholesterol levels >20 mg/dl lower than Non-Diet-Sensitive adults on a similar diet (180.1 vs 202.1 mg/dl, respectively). Conclusions. Degree of response to a low-fat, low-cholesterol diet during adolescence may identify male subjects who will have differing patterns of cholesterol change over time. (C) 1997 Academic Press.

[发布日期] 1997-09-01

[关键词] cholesterol;diet, fat-restricted;primary prevention;coronary disease