Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold

[摘要] Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4-cis-enediol scaffold is reported. The synthetic route offers straightforward and highly selective access to the enediol and its associated chiral centers. Key steps include stereocontrolled syn-aldol coupling, amide alkynylation, and asymmetric ketone reduction. (C) 2011 Elsevier Ltd. All rights reserved.

[发布日期] 2011-12-30

[关键词] cis-Enediol;SH2 domain;Stereodiversified;Alkynylation