ZINC(II)-CHLORIDE INDUCED THIOALKYLATION OF ALUMINUM ENOLATES - ENANTIOSELECTIVE SYNTHESIS OF ESTRADIOL-3-METHYL-17-TERT-BUTYL DIETHER

[摘要] Zinc(II)-chloride induced thioalkylation of the aluminium enolate 6 generated by conjugate reduction of the enone 5 leads - directly or via its trimethylsilylenol ether 6 - to alkylated hydrindanones 10 which are important intermediates in the synthesis of 19-norsteroids such as the title compound estradiol-3-methyl-17-tert-butyl diether 12.

[发布日期] 1991-09-02