A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones

[摘要] A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are applications in target synthesis allowing access to natural products isolated from Oryza sativa and HOFQ. (C) 2019 Elsevier Ltd. All rights reserved.

[发布日期] 2019-12-06

[关键词] 2-Quinolones;Cross-dehydrogenative coupling;Cu(II)-catalysis;Total synthesis