Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings

[摘要] A critical comparison of methods to prepare sterically hindered 3-aryl isoxazoles containing fused aromatic rings using the nitrile oxide cycloaddition (NOC) reveal that modification of the method of Bode, Hachisu, Matsuura, and Suzuki (BHMS), utilizing either triethylamine as base or sodium enolates of the diketone, ketoester, and ketoamide dipolarophiles, respectively, was the method of choice for this transformation. (C) 2012 Elsevier Ltd. All rights reserved.

[发布日期] 2012-12-16