ALKALOIDS FROM THE ANTARCTIC SPONGE KIRKPATRICKIA-VARIALOSA .2. VARIOLIN-A AND N(3')-METHYL TETRAHYDROVARIOLIN-B

[摘要] Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3')-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3')-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.

[发布日期] 1994-03-28