Pyridinium N-2′-pyridylaminide:: synthesis of 3-aryl-2-aminopyridines through an intramolecular radical process

[摘要] Tris(trimethylsilyl)silane (TTMSS) and azobisisobutironitrile (AIBN) promote the intramolecular heteroarylation of arenesulfonamides with pyridyl radicals under thermal conditions. The arenesulfonamides are easily prepared from pyridinium N-2'pyridylaminide. The heteroarylation process involves pyridyl radical cyclization and ipso substitution. (C) 2004 Elsevier Ltd. All rights reserved.

[发布日期] 2004-12-13

[关键词] arylation;biaryls;ipso-substitution mechanism;radicals and radical reaction;Tris(trimethylsilyl)silane