AN APPROACH TO ALPHA-SUBSTITUTED AMINES

[摘要] A number of amines have been alkylated at the position alpha to nitrogen via free radical methodology. N-(2-Iodobenzyl) 'protected' amines have been used to generate radicals which rapidly undergo a 1,5-hydrogen shift to give more stable alpha-amino radicals. These can subsequently be trapped by electron deficient alkenes to give alpha-alkylated amines.

[发布日期] 1994-11-28