Design and synthesis of chiral urea-derived iodoarenes and their assessment in the enantioselective dearomatizing cyclization of a naphthyl amide

[摘要] A novel family of urea-derived chiral iodoarenes was designed and synthesized for use in enantioselective iodine(I/III) catalysis. Their preparation required the development of a bidirectional synthetic strategy. These new chiral iodoarenes were assessed as catalysts in the dearomatizing cyclization of a naphthyl amide and provided moderate yields of product in some cases with low enantioselectivities. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-11-07

[关键词] Catalysis;Hypervalent iodine;lodoarene;Dearomatization;Cyclization