Synthesis of a library of SCF2CO2Et reagents: An access to original (ethoxycarbonyl)difluoromethylthioesters

[摘要] A library of original and shelf-stable reagents, source of the (ethoxycarbonyl)difluoromethylthio group, is reported. These reagents are applied to the functionalization of a large panel of aldehydes via a transition metal-free protocol under mild reaction conditions. This approach offers an efficient access to valuable difluoromethylthioester derivatives. (c) 2021 Elsevier Ltd. All rights reserved.

[发布日期] 2021-10-08

[关键词] Difluoromethylthioester derivatives;Fluorine chemistry;Radical process;Mild reaction conditions;Aldehydes