Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

[摘要] A series of bifunctional phosphine oxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asymmetric hydrosilylation of ketimines. bis-Phosphine oxides, hydroxyphosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide displayed the highest enantioselectivity of 60%. (C) 2019 Elsevier Ltd. All rights reserved.

[发布日期] 2019-12-13

[关键词] Hydrosilylation;Asymmetric catalysis;Phosphine oxide;Organocatalysis