Selective deoxygenation of gibberellic acid with fluoroarylborane catalysts

[摘要] Reductive late-stage functionalization of gibberellic acid is reported using three fluoroarylborane Lewis acids; (B(C6F5)(3), B(3,5-C6H3(CF3)(2)), and B(2,4,6-C6H2F3)(3)) in combination with a tertiary silane and a borane (HBCat) reductant. In each case, C-O bond activation occurs, and different products are obtained depending on the reductant and catalyst employed. (C) 2019 Elsevier Ltd. All rights reserved.

[发布日期] 2019-12-06

[关键词] Late stage functionalization;Gibberellic acid;Selective deoxygenation;Hydrosilylative deoxygenation;Fluoroarylborane