Synthetic studies toward (+)-cortistatin A

[摘要] We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6 pi-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total synthesis. (C) 2011 Published by Elsevier Ltd.

[发布日期] 2011-12-30

[关键词] Total synthesis;Angiogenesis inhibitor;Nitrone-aryne cycloaddition;6 pi-Electrocyclization