Fluorogenic probes based on polycyclic sydnone scaffolds

[摘要] We report the synthesis, photophysical characterization and kinetics of a series of polycyclic sydnone derivatives as a potential new class of fluorogenic clickable reagents. After strain-promoted cycloaddition with cyclooctyne BCN, the fluorescence generated by pyrazole products displayed up-to 115-fold fluo-rescence enhancement compared to reactants. These preliminary results are of interest for possible future applications in bioorthogonal chemistry. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-12-18

[关键词] Sydnones;Mesoionics;Click chemistry;Fluorescent probes;Cycloadditions