Stereoselective cyanation of 4-formyl and 4-imino-β-lactams: application to the synthesis of polyfunctionalized γ-lactams

[摘要] The stereoselective reaction of 4-oxoazetidine-2-carbaldehydes and their corresponding imines with cyanide-based reagents give beta-lactam alpha-aminonitriles, which are chameleonic building blocks for the controlled synthesis of a variety of new compounds including functionalized gamma-lactams, succinimide derivatives, and diamino-lactams derivatives in optically pure form. (C) 2012 Elsevier Ltd. All rights reserved.

[发布日期] 2012-12-30

[关键词] Cyanides;Imines;beta-Lactams;gamma-Lactams;Rearrangements