Siladenoserinols M-P, sulfonated serinol derivatives from a tunicate

[摘要] Four new sulfonated serinol derivatives, siladenoserinols M-P (1-4), were isolated from a tunicate of the family Didemnidae collected in Indonesia. Their chemical structures were elucidated by the interpretation of NMR and mass spectroscopic data. Two of them (2 and 4) were revealed to be disulfonate serinol derivatives, and the others were monosulfonates. Siladenoserinols A (5) and B (6), which we previously isolated from the same tunicate, inhibited the p53-Hdm2 interaction with an IC50 value of 2.0 mu M. However, 1-4 did not inhibit the activity. The result suggested that the acetyl group in the bicyclic ketal unit and/or the glycerophospholipid moiety in 5 and 6 were responsible for the inhibition of the p53-lidm2 interaction. (C) 2018 Elsevier Ltd. All rights reserved.

[发布日期] 2018-12-27

[关键词] Tunicate;Didemnidae;Sulfonated serinol derivatives