The synthesis of bisanthraquinone derivatives as DNA bisintercalating agents

[摘要] The linked bisanthraquinone derivatives 4a-c were synthesized as DNA bisintercalating agents. Starting from the aldehyde 7, the linking chain was introduced via a Grignard reaction to afford the ethers 9a-c. Subsequent anodic oxidation of these products, followed by annelation with the anion of phthalide 5 affordedthe linked anthraquinones 12. The target compounds were then obtained by selective esterification with the acid 14, followed by deprotection with anhydrous hydrogen chloride. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-12-22