RING-D MODIFICATIONS OF ELLIPTICINE .1. NEW ELLIPTICINE DERIVATIVES FROM 1-CYANO-6-METHYLELLIPTICINE

[摘要] New ellipticine derivatives are synthesized by modification of the cyanogroup of 1-cyano-6-methyl-ellipticine. This resulted in the formation of 1-acetyl- and 1-acetamido-6-methylellipticine. Deprotonation of 1-cyano-6-methylellipticine under the influence of a palladium catalyst leads to a new annelated ellipticine (9). From the derivatives obtained, 9 showed the highest cytostatic activity.

[发布日期] 1994-02-21