One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase

[摘要] We report, for the first time, the use of tryptophan synthase in the generation of L-dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis. (C) 2016 Published by Elsevier Ltd.

[发布日期] 2016-11-17

[效力级别]  Proceedings Paper

[关键词] Biotransformation;Dihalotryptophan;Alkynyltryptophan;Tryptophan synthase