Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades

[摘要] An efficient synthesis of both R- and S-enantiomers of 2-arylallyl-alpha-amino acids via a diastereoselective Pd/In mediated catalytic allylation of chiral N-sulfinyl-alpha-imino esters is described. The potential for further enhancement of molecular complexity and creating contiguous chiral centres by interfacing these processes with catalytic cyclisation-anion capture methodology is demonstrated. (c) 2006 Elsevier Ltd. All rights reserved.

[发布日期] 2006-12-25