Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives

[摘要] The C7N-aminocyclitol kirkamide was recently isolated from the plant obligate symbiont Candidatus Burkholderia kirkii and was hypothesized to be beneficial to the plant host due to its cytotoxic activity against insects and arthropods. To study its mechanism of action and inspired by its structural similarity with N-acetylglucosamine (GlcNAc) and oseltamivir, kirkamide-oseltamivir hybrid derivatives were synthesized and investigated for their biological activity. Interestingly, kirkamide analogues were reasonably potent against a known bacterial neuraminidase. (C) 2020 The Authors. Published by Elsevier Ltd.

[发布日期] 2020-12-18

[关键词] Natural products;Total synthesis;Plant microbe symbiosis;Antiviral agents;Glycosidase inhibitors