Straightforward access to 2,3-and 3,4-unsaturated derivatives of N-glycolylneuraminic acid

[摘要] The facile syntheses of previously unreported 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid are herein described. The procedure involves a ring-opening of the 4,5-oxazoline of N-acetylneuraminic acid, the acylation of the intermediate free amine, its conversion into the 4,5-oxazoline of N-glycolylneuraminic acid and the subsequent Ferrier reaction or C4 nucleophilic substitution. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-12-04

[关键词] Sialidase inhibitor;N-Glycolylneuraminic acid;Glycals;Oxazoline of sialic acid;Ferrier reaction