AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

[摘要] AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.

[发布日期] 2021-10-01

[关键词] Long-term potentiation;LTP;AMPAR amino-terminal domain;TARP;Synaptic plasticity