DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol

[摘要] The role of dopamine neurotransmission in opioid reward was investigated using a rate-independent measure for determining brain stimulation reward (BSR) thresholds. Intra-accumbens infusions of the mu- and delta-specific peptides, D-Ala(2), N-Me-Phe(4), Gly-ol(5)-Enkephalin and D-Pen(2), D-Pen(5)-Enkephalin caused significant lowering of BSR thresholds. The dopamine D1/D2 antagonist, cis-flupenthixol, blocked these effects at a dose that did not significantly alter thresholds when given alone. These data suggest both mu- and delta-opioid potentiation of BSR is dopamine dependent. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-08-01

[关键词] opioids;self-stimulation;ICS