REGIONAL NEUROPATHOLOGY IN SCHIZOPHRENIA - WHERE ARE WE - WHERE ARE WE GOING

[摘要] This paper presents a neurologic formulation for the clinical features of the schizophrenic syndrome, and tests it against a systematic, region by region review of available postmortem neuroanatomical and neuropharmacological data. Based on this review a model is proposed that postulates a developmental lesion affecting the midline neurotransmitter-specific ascending projection systems. Due to the facilitatory role these systems play in the development of the brain regions to which they project, such a lesion is one parsimonious, and testable, explanation for virtually all the clinical, laboratory, and pathological findings reported to date in schizophrenia research. A case is made for establishing a global antemortem-postmortem collaboration using a Latin square design; the alternative may be that, as has happened in the past, the best efforts of dilligent researchers around the world may lead to little improvement in our understanding of schizophrenia.

[发布日期] 1993-10-01

[关键词] CLINICOPATHOLOGICAL CORRELATION;NEUROPATHOLOGY;NEUROPHARMACOLOGY;POSTMORTEM;RECEPTOR;NEUROTRANSMITTER UPTAKE SITE;(SCHIZOPHRENIA)