Indices of orbitofrontal and prefrontal function in Cluster B and Cluster C personality disorders

[摘要] Neuropsychological studies implicate disruption of frontal systems in personality disorders. Few studies have examined the performance of Cluster B and Cluster C personality disorder patients on tests of orbitofrontal (OFC) and prefrontal (PFC) cortex function. Patients carrying diagnoses of either Cluster B (n = 56) or Cluster C (n = 19) personality disorders were compared with healthy control subjects (n = 61) on the Iowa Gambling Task and University of Pennsylvania Smell Identification Test. They also completed the Wechsler Abbreviated Scale of Intelligence as a control for general intellectual ability. On the gambling task, Cluster B and Cluster C patients made more disadvantageous decisions during certain portions of the task but overall did not differ from healthy controls. Whereas no appreciable differences in olfactory identification performances were detected between patient and healthy control groups, IQ was higher for controls and was related to Cluster B patients' lower educational levels. Overall, there was limited evidence for neurocognitive inefficiency for personality disorder groups on tests sensitive to OFC and PFC function. The present study is among the first to report neurocognitive findings for the full range of Cluster B personality disorders and any Cluster C personality disorder. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

[发布日期] 2009-12-30

[关键词] Borderline personality disorder;Olfaction;Iowa Gambling Task;Prefrontal cortex;Orbitofrontal cortex