Voltage-gated potassium channel antibodies associated limbic encephalitis in a patient with invasive thymoma

[摘要] Recently, limbic encephalitis (LE) associated with Voltage-gated potassium channel antibody (VGKC-Ab) has been postulated as a new autoimmune disorder. Most previously reported cases of VGKC-Ab-associated LE were non-paraneoplastic, and reports of a paraneoplastic type are rare. Here we describe a 59-year-old woman with paraneoplastic VGKC-Ab-associated LE preceding the recurrence of invasive thymoma. There was a close temporal relationship between the clinical course and the changes of the VGKC-Ab titer. Unlike many of the non-paraneoplastic VGKC-Ab-associated LE cases, our cases showed the more extensive high intensity lesions on MRI and the absence of seizure and hyponatremia. (c) 2006 Elsevier B.V. All rights reserved.

[发布日期] 2006-12-01

[关键词] voltage-gated potassium channel antibody;linibic encephalitis;invasive thymoma