Novel synthetic ligands for targeted PET imaging and radiotherapy of copper

[摘要] Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with Cu-64, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with Cu-64. (C) 2007 Elsevier Ltd. All rights reserved.

[发布日期] 2007-11-15

[关键词] synthetic chelates;macrocyclic ligands;Cu-64;PET imaging;targeted radiotherapy;serum stability