Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

[摘要] A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. Highthroughput screening of this library for anti -tuberculosis activity identified several members with a MIC90 value of 12.5 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.

[发布日期] 2007-12-15

[关键词] mureidomycins;uridine-based library;solid-phase synthesis;IRORI technology;anti-tuberculosis activity;tuberculosis;antibiotic