Solution-phase synthesis of a combinatorial monocyclic β-lactam library:: Potential protease inhibitors

[摘要] A 126-member library of monocyclic beta-lactams was generated in parallel fashion by solution-phase Ugi four-component condensation reaction between beta-amino acids, aldehydes, and isocyanides, The library was designed to identify potential human leukocyte elastase inhibitors. The approach is also capable of optimizing the lead compounds generated in the original library. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-12-16