5'-Halogenated analogs of oxymorphindole

[摘要] The presence of a 6,7-fused indole group in the indoloniorphinans was considered to be responsible for the delta opioid selectivity for this class of ligands. Herein is shown that 5'-halogenated analogs of oxymorphindole are opioids with little selectivity for delta receptors over mu opioid receptors. (c) 2007 Elsevier Ltd. All rights reserved.

[发布日期] 2007-11-01

[关键词] tolerance;dual-profile ligands