Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro

[摘要] Robustaflavone, a naturally occurring biflavanoid isolated from the seed kernel extract of Rhus succedanea, was found to be a potent in vitro inhibitor of hepatitis B, with an effective concentration (EC50) of 0.25 mu M and an in vitro selectivity index (IC50/EC90) of 153. Further studies suggested that inhibition of HBV DNA polymerase is the mechanism of action. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-09-09